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pThe most frequent adverse reaction to Zyloprim is skin rashSkin reactions can be severe and sometimes fatalThereforetreatment with Zyloprim should be discontinued immediately if a rash developssee WARNINGSSome patients with the most severe reaction also had feverchillsarthralgiascholestatic jaundiceeosinophilia and mild leukocytosis or leukopeniaAmong 55 patients with gout treated with Zyloprim for 3 to 34 monthsaverage greater than 1 yearand followed prospectivelyRundles observed that 3of patients developed a type of drug reaction which was predominantly a pruritic maculopapular skin eruptionsometimes scaly or exfoliativeHoweverwith current usageskin reactions have been observed less frequently than 1The explanation for this decrease is not obviousThe incidence of skin rash may be increased in the presence of renal insufficiencyThe frequency of skin rash among patients receiving ampicillin or amoxicillin concurrently with Zyloprim has been reported to be increasedsee PRECAUTIONS/ppAvoid drinking alcohol while taking allopurinolas it may make your condition worseAllopurinol may impair your thinking or reaction timeso you should be especially careful when driving or performing any activity that requires you to be alert./ppIf you are taking any of these medicationsspeak with your doctor or pharmacistDepending on your specific circumstancesyour doctor may want you to:/ppSome patients with pre-existing renal disease or poor urate clearance have shown a rise in BUN during administration of ZyloprimAlthough the mechanism responsible for this has not been establishedpatients with impaired renal function should be carefully observed during the early stages of administration of Zyloprim and the dosage decreased or the drug withdrawn if increased abnormalities in renal function appear and persist./p

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